Table 3

The induction of intranasal tolerance to RE induced experimental autoimmune uveoretinitis (EAU) is retinal antigen specific

Tolerising antigen Incidence (eyes) Median clinical severity Median histological score (range)
IRBP (50 μg/ml)5/120.51.5  (1–3)
IRBP (1 μg/ml)11/1212  (1–3)
S-Ag (20 μg/ml)9/1211  (0.5–1.5)
MBP (30 μg/ml)12/1222  (1–4)
PBS10/1233  (2–4)
  • Animals were immunised subcutaneously with 290 μg of retinal extract w/v complete Freund’s adjuvant.

  • Each histological score at day 21 after immunisation represents the median score derived from separate analysis of all eyes with disease. Median clinical score was derived from of all eyes in each group.