Table 1

Physiological variables in rats treated with saline or NG-nitro-l-arginine methyl ester (L-NAME)

Control Acute L-NAME Chronic L-NAME
Rectal temperature (°C)37.1 (0.2)36.4 (1.4)36.8 (1.0)
Plasma glucose (g/l)1.64 (0.06)1.62 (0.08)1.60 (0.07)
pH7.43 (0.01)7.42 (0.05)7.44 (0.02)
Pco 2 (mm Hg)40.9 (1.1)41.0 (4.0)39.1 (1.4)
Po 2 (mm Hg)93.8 (3.0)91.7 (5.1)93.4 (3.8)
Heart rate (beats/min)360 (11)352 (8)350 (7)
MAP (mm Hg)135 (2)177 (3) 202 (6)
  • Data are presented as mean (SEM) for each of the three treatment groups (n=10 in each group).

  • Significantly different from control (p<0.05); Significantly different from acute treatment group.

  • MAP=mean arterial pressure.