Table 2

Blood flow and deoxyglucose uptake in ocular and cerebral tissues of rats treated with either saline or NG-nitro-l-arginine methyl ester (L-NAME)

Ocular tissue Cerebrocortical tissue
Control Acute
Chronic L-NAME Control Acute
Blood flow (ml/100 g/min)67 (3)35 (4) 29 (3) 140 (10)80 (6) 134 (8)
Deoxyglucose uptake (per 100 g)19.9 (3.6)20.4 (3.8)20.2 (3.5)44.8 (2.8)45.1 (3.4)46.2 (3.1)
Flow/metabolism ratio3.3671.7161.4363.1251.7742.900
  • Data are presented as mean (SEM) for each of the three treatment groups (n=5 in each group for both the blood flow and glucose utilisation measurements).

  • Significantly different from control (p<0.005); significantly different from appropriate acute treatment group.