Pharmacokinetic analyses of mitomycin C (MMC) concentration changes in the conjunctiva
| Method of MMC application | MMC dosage applied (μg) | Initial concentration (μg/g) | Time constant (h−1) | Half life (h) | AUC (μg h/g) | |
| Current study with reversible thermosetting gel | 0.22 2.9 | 1.23 5.26 | 2.40 1.78 | 0.29 0.39 | 0.40 3.2 | |
| 28 | 140.28 | 1.80 | 0.39 | 57.0 | ||
| Subconjunctival injection with sterile water | 2 | 1.05 | 2.28 | 0.31 | 0.29 | |
| 20 | 5.76 | 2.33 | 0.30 | 1.03 | ||
| 200 | 158.0 | 3.92 | 0.18 | 23.49 | ||
| Application with sponges for 5 minutes and copious irrigation |
200 | 12.6 | 2.33 |
0.30 |
5.18 | |