Pharmacokinetic analyses of mitomycin C (MMC) concentration changes in the sclera
| Method of MMC application | MMC dosage applied (μg) | Initial concentration (μg/g) | Time constant (h−1) | Half life (h) | AUC (μg h/g) | |
| Current study with reversible thermosetting gel | 0.22 | 0.10 | 1.31 | 0.53 | 0.11 | |
| 2.9 | 0.56 | 1.49 | 0.47 | 0.80 | ||
| 28 | 66.68 | 2.03 | 0.34 | 22.42 | ||
| Subconjunctival injection with sterile water | 2 | 0.12 | 1.54 | 0.45 | 0.14 | |
| 20 | 0.62 | 1.82 | 0.38 | 0.14 | ||
| 200 | 20.0 | 3.41 | 0.20 | 4.23 | ||
| Application with sponges for 5 minutes and copious irrigation |
200 |
3.16 |
2.19 |
0.32 |
0.67 | |