Reference No | ||||||||
---|---|---|---|---|---|---|---|---|
4 | 5 | 11 | 14 | 23 | 29 | 15 | 24 | |
1 | ||||||||
(A) Random allocation | No | Yes | Yes | Yes | Yes | No | Yes | Yes |
(B) Description of randomisation | I | I | A | P | I | I | I | P |
(C) Potential bias in treatment assignment | Yes | No | No | No | No | Yes | No | Yes |
2 | ||||||||
(A) Description of outcome measures | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
(B) Criteria objective | P | P | Yes | Yes | Yes | P | P | P |
(C) Outcome assessors masked to treatment | No | No | Yes | No | Yes | No | Yes | Yes |
3 | ||||||||
(A) Inclusion/exclusion criteria defined | No | No | P | No | No | P | Yes | Yes |
(B) Mention of patients not included | No | No | No | No | No | No | No | No |
4 | ||||||||
(A) Therapy described for treatment group | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes |
(B) Therapy described for control group | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
5 (A) | ||||||||
1 Statistical analysis test stated | Yes | No | Yes | Yes | Yes | Yes | Yes | Yes |
2 p Value stated | No | No | Yes | Yes | No | Yes | Yes | Yes |
(B) Statistical analysis appropriate | Yes | NA | Yes | Yes | P | Yes | Yes | Yes |
(C) If negative trial, CI and post hoc power calculations performed | NA | NA | No | No | NA | NA | NA | NA |
(D) Sample size justification before study | No | No | No | No | No | No | No | No |
Final score | 0.39 | 0.46 | 0.73 | 0.6 | 0.53 | 0.42 | 0.67 | 0.71 |
A=adequate; P=partial; I=inadequate; CI=confidence intervals; NA=not applicable.
↵Sample size limitations are discussed.