Trabeculectomies performed with the adjunct of PBS (control), mitomycin C (treated control), or suramin. Results show the days of failure of the surgical procedure
| Group, surgery | Animals (n) | Concentration (mg/ml) | No of applications | Time until failure (days) | p Value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SEM | ||||||||||
| 1, controls | 7 | — | 0 | 4.7 | 0.5 | — | |||||
| 2, MMC | 7 | 0.5 | 1 | 8.2 | 0.5 | 0.001 | |||||
| 3, suramin | 3 | 10 | 5 | 5 | 0.85 | ||||||
| 4, suramin | 3 | 100 | 5 | 7 | 0.001 | ||||||
| 5, suramin | 3 | 200 | 5 | 9 | 0.001 | ||||||
| 6, suramin | 3 | 333 | 5 | 14 | 0.001 | ||||||
MMC = mitomycin C.
↵1 = one application during surgery; 5 = one application during surgery followed by subconjunctival injections for each of the next 4 days.
p Value = Student’s t test for unpaired observations, compared with controls.