Table 3

Healing of ulcer by day 21 in 64 ulcers with positive microscopy: comparison of the two treatments

(A) All fungal ulcers
Stratum and treatment groupNo of patientsUlcer healed by day 21 (%)Relative efficacy (CHX/natamycin)
Non-severe ulcers:
 Chlorhexidine2114  (66.7)1.85
 Natamycin259 (36.0)
Severe ulcers:
 Chlorhexidine110
 Natamycin70
All ulcers:
 Chlorhexidine3214 (43.8)1.56
 Natamycin329 (28.1)
Summary stratified analysis:1.85 (95% CL 1.01–3.39, p=0.04)
(B) Healing of ulcers by day 21 in 57 patients with positive culture: comparison of two treatments
Stratum and treatment group No of patients Ulcer healed by day 21 (%) Relative efficacy (CHX/natamycin)
Non-severe ulcers:
 Chlorhexidine169  (56.3)1.85
 Natamycin237 (30.4)
Severe ulcers:
 Chlorhexidine110
 Natamycin70
All ulcers:
 Chlorhexidine279 (33.3)1.43
 Natamycin309 (23.3)
Summary stratified analysis: 1.85 (95% CL 0.87–3.93, p=0.1)