Table 1

Summary of the pathological findings in the TPras mice and the control mice

Pathological findings in mice eyes
Number Age Type Ocular pathology Neuropathology EM
13 weeksrasiris/ciliary body moderately pigmented melanomanormalno
26 weeksrasmelanocytic/RPE hamartomabenign melanocytic proliferationyes
37 weeksrasmelanocytic/RPE hamartomanoyes
45 monthsrasmelanocytic/RPE hamartomanormalyes
54 monthsrasmelanocytic/RPE hamartomanoyes
69 monthsrasmelanocytic/RPE hamartomabenign melanocytic proliferationno
711 monthsrasmelanocytic/RPE hamartomanormalno
811 monthsrasiris/ciliary body moderately pigmented melanomanoyes
93 weeksnormalnormalnormalno
105 weeksnormalRPE proliferationnormalyes
113 monthsnormalnormalnormalyes
129 monthsnormalnormalnormalno
139 monthsnormalnormalnoyes
1411 monthsnormalnormalnono