Table 2

Transgenic model of ocular tumours

InvestigatorModel nameTarget geneRPEPredominant cell type
MelanocytesMetastases
Bradl, Klein-Szanto, 1991Tyr-SV40ESV40RPE proliferationsNot reportedNumerous organs
Anand, 1994SV40SV40RPE proliferationsNot reportedLiver
Syed, 1995,1996Tyr-Tag A, Tyr-Tag BSV40RPE, spindle, and epithelioid cellsNot reportedMuscle and spleen in
Tag A mice
Powell, 1995TprasT24 Ha-rasRPEMelanocytes and melanomaLung and lymph nodes (induced skin)