Investigator | Model name | Target gene | RPE | Predominant cell type | |||||
---|---|---|---|---|---|---|---|---|---|
Melanocytes | Metastases | ||||||||
Bradl, Klein-Szanto, 1991 | Tyr-SV40E | SV40 | RPE proliferations | Not reported | Numerous organs | ||||
Anand, 1994 | SV40 | SV40 | RPE proliferations | Not reported | Liver | ||||
Syed, 1995,1996 | Tyr-Tag A, Tyr-Tag B | SV40 | RPE, spindle, and epithelioid cells | Not reported | Muscle and spleen in Tag A mice | ||||
Powell, 1995 | Tpras | T24 Ha-ras | RPE | Melanocytes and melanoma | Lung and lymph nodes (induced skin) |