Patient characteristics (n=70)
| Variable | Value |
|---|---|
| Age (years) | |
| mean (SD) | 53.3 (13.1) |
| range | 27-74 |
| Sex (F/M) | 50/20 |
| Duration GO (months) | |
| median (range) | 12.0 (1–206) |
| Duration GTD (months) | |
| median (range) | 18.0 (0–456) |
| Severity of GO (NO SPECS) | |
| soft tissue involvement: class 2 (0/a/b/c) | 6/42/19/3 |
| proptosis: class 3 (0/a/b/c) | 52/11/7/0 |
| extraocular muscle involvement: class 4 (0/a/b/c) | 11/26/30/3 |
| corneal involvement: class 5 (0/a) | 69/1 |
| optic nerve involvement: class 6 (0/a/b/c) | 67/0/3/0 |
| TES (median (range)) | 9 (2–28) |
| Activity of GO (CAS (mean (SD))) | 2.6 (1.3) |
GO=Graves’ ophthalmopathy; GTD=Graves’ thyroid disease.
↵TES=total eye score is calculated by multiplying each class of the NO SPECS system (except class 5) with its grade of severity (0=0; a=1; b=2; c=3 points), yielding a maximum total score of 45 points14 (Since all patients had symptoms, class 1 is not taken into account).
↵CAS=clinical activity score is based on signs of pain, redness, swelling, and impaired function (range 0-7).