Adverse event | Latanoprost | Timolol-pilocarpine |
Ocular | (n=39) | (n=94) |
Ocular discomfort | 33 | 70 |
Blurred vision | 2 | 54 |
Decreased visual acuity | 4 | 18 |
Decreased twilight vision | 1 | 14 |
Visual field changes/scotoma | 4 | 11† |
Photophobia | 0 | 9 |
Eyelid pain and discomfort | 2 | 9 |
Conjunctival hyperaemia | 7 | 5 |
Increased IOP | 1 | 3 |
Punctate corneal erosions | 2 | 0 |
Conjunctivitis | 1 | 2 |
Other | 13 | 12 |
Systemic | (n=11) | (n=36) |
Headache | 4 | 25 |
Dizziness | 1 | 4 |
Influenza | 4 | 1 |
Vertigo/imbalance | 1† | 4 |
Nausea | 0 | 1 |
Other | 3† | 9† |
In parenthesis, n = number of patients reporting adverse events.
↵Ocular discomfort includes burning, itching, tearing, dry eye, stinging, foreign body eye sensation, and eye pain. †Some events reported as serious adverse event, a total of six patients for both treatments groups. Please see text for explanation.