HSV-1 in tears following ocular challenge †
| Days post challenge | CD8+ deficient | CD4+ deficient | C57BL/6J | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CD8−/− | Depleted | CD4−/− | Depleted | ||||||
| Day 1 | 100% | 100% | 100% | 100% | 100% | ||||
| Day 2 | 100% | 100% | 100% | 100% | 100% | ||||
| Day 3 | 100% | 100% | 100% | 100% | 100% | ||||
| Day 4 | 100% | 100% | 100% | 100% | 100% | ||||
| Day 5 | 100% | 100% | 100% | 100% | 100% | ||||
| Day 6 | 60% | 50% | 80% | 80% | 60% | ||||
| Day 7 | 50% | 50% | 80% | 80% | 50% | ||||
| Day 8 | 0% | 0% | 60% | 50% | 0% | ||||
| Day 9 | 0% | 0% | 20% | 30% | 0% | ||||
| Day 10 | 0% | 0% | 10% | 20% | 0% | ||||
| Day 11 | 0% | 0% | 0% | 0% | 0% | ||||
↵Mice were challenged ocularly with 2×106 pfu/eye of HSV-1 McKrae as described in Materials and methods. Tears were collected from five mice (10 eyes) on the days indicated using a Dacron swab and plated on RS indicator cells to determine the presence of infectious virus. †Percentage eyes with detectable virus.