Table 1

HSV-1 in tears following ocular challenge

Days post challengeCD8+ deficientCD4+ deficient C57BL/6J
Day 1100%100%100%100%100%
Day 2100%100%100%100%100%
Day 3100%100%100%100%100%
Day 4100%100%100%100%100%
Day 5100%100%100%100%100%
Day 660%50%80%80%60%
Day 750%50%80%80%50%
Day 80%0%60%50%0%
Day 90%0%20%30%0%
Day 100%0%10%20%0%
Day 110%0%0%0%0%
  • Mice were challenged ocularly with 2×106 pfu/eye of HSV-1 McKrae as described in Materials and methods. Tears were collected from five mice (10 eyes) on the days indicated using a Dacron swab and plated on RS indicator cells to determine the presence of infectious virus. Percentage eyes with detectable virus.