Table 1

Hereditary models for retinal degenerations

Strain Trivial name Gene Mutation type Cell layer Degeneration time course References
Mouse models:
 C57BL/6Jrd β phosphodiesterase null mutationONLp8–p21 3, 4
 C57BL/6rds Peripherin null mutationONLp21–1 year 19, 20
 C57BL/6Jtubby (rd5) tub ONLp14–9–12 months 21, 107, 108
 C57BL/6Jvitiligo (mivit/mivit)microphthalmia (mi)  geneONL, OPL8 weeks–8 months 109, 110
 RBF/DnJrd3 rd3 ONLp21–8 weeks 111
 C57BL/6Jpcd pcd (Chr 13)ONLinitial degeneration p25,  never complete 112
 DBA/2J × C57BL/6Jrd4 rd4 inversionONL, OPLp10–6 weeks 113
 C57BL/6J × Krd/+Krdon Chr 19, including  Pax2 deletionentire retinainitial malformation at E  10.5 114
Others:
 catAbyssinian cat rdy ONLp22–27 months 6, 7, 10
 chickenRhode Island Red  chickenphotoreceptor guanylate  cyclase (GC1)null mutationONLstarts at p7 15, 16
 doglabrador retriever rdy ONL1–2 months–18 months 13
 dogSwedish briard Rpe65 deletionManifest at 10 months 11, 48, 49, 51
 dogIrish setter β phosphodiesterase nonsense mutationONLp25–1 year 11, 12, 14
 ratFischer 344 rhodopsin point mutatiuonONL4–8 months–2 years 17, 18
 ratRCS rdy ONLp21–7 weeks115–117