Table 6

Comparative estimates of the MMP content of the tears of healthy individuals and patients with ocular disease

MMP zymographic activity/unit protein
Diagnostic groupNo of sampleMr 116 000MMP-9
Group 1 (normal)100.07 (0.09)0.14 (0.19)
 Normal?10.050.90
Group 2a (keratoconus) (1–8)70.27 (0.32)0.51 (0.30)
Group 2b (keratoconus) (9–15)71.70 (0.96)4.32 (1.90)
Group 3
 Microbial keratitis20.15 (0.07)0.25 (0.21)
 Rosacea keratitis2NDND
 Thygeson's keratitis10.100.40
 Acanthamoeba21.70 (0.5)2.55 (1.9)
Group 4 (herpes)41.70 (1.13)4.57 (2.2)
Group 5
 Sjogren's syndrome40.62 (0.46)3.68 (1.46)
 Dry eye (non-Rh)50.99 (0.48)3.74 (0.78)
  • ND = not detected; Rh = rheumatoid arthritis.