Table 3

Percentage IOP reduction from baseline with latanoprost and timolol

Trial		Percentage IOP reduction (mean (SE))		Difference of the reduction (95% CI)	p Value
Trial		Latanoprost	Timolol	Difference of the reduction (95% CI)	p Value
1 week
Diestelhorst et al199832	19.8 (6.2)	11.3 (5.4)	8.5 (−7.6, 24.7)	0.30
Nicolela et al199635	25.5 (5.8)	19.8 (5.3)	5.62 (−9.9, 21.1)	0.48
Rulo et al199436	31.2 (2.8)	24.4 (2.9)	6.85 (−1.0, 14.7)	0.09
Pooled	28.7 (2.3)	21.2 (2.3)	6.9 (0.4, 13.4)	0.04
χ² _heter	3.16	4.59	0.07
1 month
Diestelhorst et al199832	19.4 (5.6)	8.5 (2.4)	11.0 (−0.9, 22.8)	0.07
Mishima et al199634	24.1 (1.3)	19.9 (1.1)	5.2 (1.9, 8.4)	0.00
Watson et al199637	34.3 (1.5)	34.0 (1.5)	0.4 (−3.9, 4.6)	0.86
Pooled	27.3 (4.0)	20.9 (6.3)	3.8 (1.2, 6.3)	0.00
χ² _heter	24.64	94.22	4.57
3 months
Alm et al199527	33.7 (2.6)	29.7 (1.7)	4.0 (−2.1, 10.1)	0.20
Aquino et al199928	37.1 (4.0)	31.7 (3.8)	5.41 (−5.5, 16.3)	0.16
Mastropasqua et al199933	24.9 (2.9)	21.7 (2.8)	3.2 (−4.7, 11.1)	0.42
Mishima et al199634	26.8 (1.3)	19.0 (1.1)	7.8 (−4.4, 11.2)	0.00
Watson et al199637	34.7 (1.4)	32.8 (1.5)	1.9 (−2.2, 6.1)	0.37
Pooled	31.2 (2.3)	26.9 (3.4)	5.0 (2.8, 7.3)	0.00
χ² _heter	24.01	65.50	4.97
6 months
Alm et al199527	32.1 (2.6)	27.2 (1.7)	4.8 (−1.3, 11.0)	0.12
Camras et al199629	26.5 (1.2)	19.4 (1.0)	7.1 (4.0, 10.2)	0.00
Mastropasqua et al199933	24.5 (4.3)	20.0 (3.0)	4.5 (−5.7, 14.8)	0.39
Watson et al199637	34.7 (1.4)	33.2 (1.5)	1.5 (−2.8, 5.6)	0.47
Pooled	29.9 (2.6)	25.0 (3.7)	5.0 (2.8, 7.3)	0.00
χ² _heter	21.14	64.61	4.57
12 months
Mastropasqua et al199933	24.1 (4.6)	19.2 (3.1)	4.9 (−5.9, 15.8)	0.37

IOP= introcular pressure. Percentage IOP reduction = (baseline IOP − end point IOP)/baseline IOP × 100%. SE = standard error. χ²_heter = χ² test statistic for heterogeneity.
↵p<0.001, random effects model were used for pooling.