Risk of side effects with latanoprost and timolol
| Side effects | No of trials | Crude event rate | RR (95% CI) | RD (95% CI) | NNH (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Latanoprost | Timolol | ||||||||||
| Withdrawals due to adverse effects | 2 | 9/277 | 14/285 | 0.70 (0.30, 1.66) | −0.02 (−0.05, 0.16) | NA | |||||
| Hyperaemia | 6 | 51/586 | 20/503 | 2.20 (1.33, 3.65) | 0.05 (0.02, 0.07) | 21 (14, 42) | |||||
| Conjunctivitis | 3 | 7/419 | 5/320 | 0.80 (0.25, 2.53) | 0.006 (−0.001, 0.02) | NA | |||||
| Increased pigmentation | 4 | 21/478 | 0/387 | 8.01 (1.87, 34.30) | 0.03 (0.01, 0.04) | 36 (22, 91) | |||||
| Hypotension | 1 | 0/149 | 2/145 | 0.19 (0.01, 4.02) | −0.01 (−0.04, 0.01) | NA | |||||
| Bradycardia | 1 | 0/87 | 2/91 | 0.21 (0.01, 4.29) | −0.02 (−0.06, 0.02) | NA | |||||