Percentage IOP reduction from baseline with evening regimen and morning regimen of latanoprost (3 month treatment)
| Trial | Percentage IOP reduction (mean (SE)) | Difference of IOP reduction | p Value | ||||
|---|---|---|---|---|---|---|---|
| Evening | Morning | ||||||
| Almet al 199527 | 35.7 (1.6) | 31.0 (2.0) | 4.6 (2.6) | 0.08 | |||
| Alm et al 199545 | 36.7 (3.6) | / | / | / | |||
| Mastropasqua et al199933 | 24.9 (2.9) | / | / | / | |||
| Mishimaet al 199634 | / | 26.8 (1.3) | / | / | |||
| Watson et al199637 | 34.7 (1.4) | / | / | / | |||
| Pooled | 33.2 (1.4) | 28.1 (1.1) | 5.1 (1.8) | 0.006 | |||
| χ2 heter | 12.00 | 3.02 | / | / | |||
IOP = introcular pressure.
Percentage IOP reduction = (baseline IOP − end point IOP)/baseline IOP × 100%.
SE = standard error.
χ2heter = χ2 test statistic for heterogeneity.
↵p<0.001, random effects model were used for pooling.