Univariate Cox proportional hazard regression analysis for recurrence free survival of 34 out of 69 patients with conjunctival melanomas who developed local recurrence
| Parameter | RR (relative risk) | 95% CI | p Value* |
|---|---|---|---|
| *All p values are two sided. | |||
| †As “favourable” were classified melanomas located on the bulbar conjunctiva and limbus and as “unfavourable” those located at the palpebral conjunctiva, caruncle, plica, or fornices. | |||
| Age | |||
| >60 years | 1.01 | 0.6–1.7 | 0.96 |
| Ref: ≤60 years | |||
| Multifocality (continuous) | 1.17 | 0.78–1.75 | 0.45 |
| Growth pattern | |||
| Nodular or mixed | 1.06 | 0.98–1.14 | 0.14 |
| Ref: superficial | |||
| Sex | |||
| Male | 0.86 | 0.42–1.77 | 0.86 |
| Ref: female | |||
| Histological cell type | |||
| Epithelioid and mixed | 2.9 | 1.0–8.48 | 0.05 |
| Ref: spindle | |||
| Grade of invasion | |||
| Deeper than subst propria | 3.9 | 1.42–10.71 | 0.008 |
| Ref: subst propria | |||
| Location† | |||
| Unfavourable | 0.87 | 0.42–1.77 | 0.69 |
| Ref: favourable | |||
| Surgical excision | |||
| Not in toto | 3.55 | 1.38–9.1 | 0.008 |
| Ref: in toto | |||
| Adjuvant therapy | |||
| No | 1.25 | 0.79–1.96 | 0.34 |
| Ref: yes | |||
| Grade of pigmentation | |||
| Amelanotic or mixed | 2.0 | 1.35–3.07 | 0.0007 |
| Ref: melanotic | |||
| Clinical origin | |||
| PAM or de novo | 0.87 | 0.49–1.53 | 0.63 |
| Ref: naevus | |||