Table 1

LOD scores obtained for crystallin loci genotyped in three large cataract pedigrees

PedigreeGeneMarker0.00.10.20.30.4Max LODθ
*Two crystallin genes are represented by one microsatellite marker at these loci.
†CRYAB and CRYBB1 were not screened by SSCP as they were not reported in the literature at the time of the investigation.
Crch30CRYGC/GD*D2S2358−8.62−3.39−1.78−0.89−0.330.000.50
CRYAB†D11S1347−5.25−1.48−0.84−0.46−0.190.000.50
CRYBA1D17S8410.100.080.070.050.020.100.00
CRYAAD21S1890−0.690.300.290.180.060.320.14
CRYBB1/BB2*†D22S926−4.10−1.23−0.64−0.35−0.150.000.50
Crch32CRYGC/GD*D2S2358−20.87−3.39−1.64−0.50−0.020.040.45
CRYAB†D11S1347−5.210.530.650.520.290.660.18
CRYBA1D17S841−7.33−2.00−0.72−0.140.060.070.42
CRYAAD21S1890−6.62−1.38−0.220.160.170.200.37
CRYBB1/BB2*†D22S926−16.44−7.70−1.11−2.05−0.780.000.50
Ctas17CRYGC/GD*D2S23582.943.612.891.880.803.720.06
CRYBA1D17S841−11.27−4.06−2.10−1.03−0.390.000.50