100 mg timolol iv (alone) | 500 mg dorzolamide iv (after timolol) | 500 mg dorzolamide iv (alone) | 100 mg timolol iv (after dorzolamide) | 500 mg dorzolamide+100 mg timolol iv | |
---|---|---|---|---|---|
*A statistically significant difference (p<0.05) between baseline and 30 minute values, tested with Student’s t test. | |||||
ONPO2 (baseline) (kPa) | 4.33 (0.25) | 4.23 (0.19) | 2.96 (0.62) | 4.00 (0.90) | 3.24 (1.06) |
ONPO2 (30 min) (kPa) | 4.22 (0.19) | 5.09 (0.48)* | 3.69 (0.88)* | 4.19 (1.11)* | 4.08 (0.92)* |
apH (baseline) | 7.40 (0.01) | 7.41 (0.01) | 7.41 (0.01) | 7.33 (0.02) | 7.41 (0.01) |
apH (30 min) | 7.41 (0.01) | 7.33 (0.02)* | 7.34 (0.01)* | 7.32 (0.01)* | 7.33 (0.01)* |
aPCO2 (baseline) (kPa) | 7.2 (0.6) | 7.0 (0.6) | 7.2 (0.4) | 8.4 (0.5) | 6.7 (0.2) |
aPCO2 (30 min) (kPa) | 7.0 (0.6) | 8.4 (0.5)* | 8.2 (0.4)* | 8.6 (0.4)* | 8.0 (0.4)* |
aPO2 (baseline) (kPa) | 10.6 (1.0) | 10.1 (0.8) | 11.9 (1.5) | 10.9 (2.1) | 11.1 (2.4) |
aPO2 (30 min) (kPa) | 10.1 (0.8) | 10.2 (0.8) | 12.3 (1.4) | 10.9 (2.2) | 11.1 (2.4) |
MAP (baseline) (mm Hg) | 114 (16) | 108 (11) | 99 (20) | 84 (27) | 99 (20) |
MAP (30 min) (mm Hg) | 110 (12) | 99 (16) | 89 (23)* | 77 (26)* | 87 (20)* |
HR (baseline) | 86 (7) | 89 (5) | 99 (20) | 86 (11) | 94 (30) |
HR (30 min) | 89 (5) | 85 (8)* | 89 (23) | 89 (11) | 87 (21) |