Table 2

Ophthalmoscopic, electroretinographic, and histological findings with increasing doses of intravitreal tenecteplase

Tenecteplase dose (μg)
50 (n = 7)150 (n = 5)200 (n = 5)250 (n = 7)
TRD  =  tractional retinal detachment; RA  =  retinal atrophy; RN  =  retinal necrosis; VF  =  vitreal fibrosis.
OphthalmoscopyNormalNormalTRD(2)TRD(3)
RA(1)RN(2)
Normal(2)VF(2)
ERG B-wave amplitudeNo reductionTransitory reductionSignificant reductionSignificant reduction
Retinal histologyNormalMild damageSignificant damageSignificant damage