Technique | Parameter | Sample size |
---|---|---|

Sample sizes are given based on a two way crossover design using pairwise analysis, a double sided α error of 0.05, and a β error of 0.20 in order to detect a 10% difference between treatment groups. All sample sizes are rounded up to even numbers to allow for balanced randomisation. | ||

AU, arbitrary units. | ||

Pneumotonometry | Pulsatile ocular blood flow (µl/min) | 12 |

Laser interferometry in the macula | Fundus pulsation amplitude (µm) | 4 |

Colour Doppler imaging in the ophthalmic artery | Peak systolic velocity (cm/s) | 8 |

End diastolic velocity (cm/s) | 14 | |

Mean flow velocity (cm/s) | 8 | |

Colour Doppler imaging in the posterior ciliary arteries | Peak systolic velocity (cm/s) | 18 |

End diastolic velocity (cm/s) | 18 | |

Mean flow velocity (cm/s) | 10 | |

Laser Doppler flowmetry in the macula | FLOW (AU) | 14 |

VEL (AU) | 8 | |

VOL (AU) | 12 |