Effect of doxycycline on MMP and TIMP synthesis in corneal cell cultures
| Doxycycline (μM) | MMP-1 | MMP-2 | MMP-9 (pmol/mg) | TIMP-1 | TIMP-2 |
|---|---|---|---|---|---|
| *Culture numbers = 5. | |||||
| Epithelial cells* | |||||
| 0 | 8.2 (0.8) | 92.0 (25.2) | 53.7 (14.3) | 98.2 (11.9) | 227.8 (22.1) |
| 100 | 7.7 (0.6) | 87.7 (27.8) | 51.3 (19.9) | 108.0 (10.8) | 226.5 (19.1) |
| 200 | 5.8 (1.6) | 79.0 (28.9) | 41.6 (12.8) | 98.0 (38.0) | 192.0 (25.4) |
| Keratocytes* | |||||
| 0 | 8.3 (1.9) | 97.2 (20.2) | <2.0 | 131.2 (18.1) | 202.0 (20.7) |
| 100 | 7.6 (1.4) | 80.8 (9.4) | <2.0 | 122.3 (15.0) | 205.0 (25.2) |