Table 3

 50 Most abundant genes expressed by native macular RPE cells

Gene nameGenBank Acc NoSignal (AU)*Biological function
*AU, arbitrary units.
†Indicate genes not in the top 50 of cultured RPE cells (any condition).
Cut-like 1, CCAAT displacement protein (Drosophila)AA28440849.2Development
cDNA FLJ34046 fis, clone FCBBF2007610W1546544.7Unknown
Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12N4985637.7Neurotransmitter
Nephronophthisis 3 (adolescent)H9311836.3Unknown
Junctional adhesion molecule 2R6846436.2Cell adhesion
Prefoldin 4AA25343035.9Protein folding
Selenoprotein TR7851633.5Antioxidant
Ubiquitin conjugating enzyme E2I (UBC9 homologue, yeast)AA48719733.1Protein degradation
Biogenesis of lysosome related organelles complex-1, subunit 1H9485732.2Unknown
CDC28 protein kinase regulatory subunit 1BAA45929231.4Cell cycle
d-dopachrome tautomerase mRNA, complete cdsAA29299531.0Unknown
Zinc finger protein 258AA28067629.4Development
Endothelin converting enzyme 1AA27942928.6Cell-cell signalling
Multiple endocrine neoplasia IAA26179627.6Transcription regulation
CDC28 protein kinase regulatory subunit 2AA39781327.0Cell cycle
Interleukin 24AA28163526.5Immune response, apoptosis
Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1AA44818424.9electron transport
Profilin 1AA52143123.5Cell structure
BCL2 related protein A1AA45926323.1Apoptosis inhibition
Kinesin family member 5BAA04669021.9Organelle transport
Rho GTPase activating protein 1†AA44350621.5Cell structure
Adaptor related protein complex 1, γ1 subunitW0730021.5Protein sorting
NudE nuclear distribution gene E homologue-like 1 (A. nidulans)R9477521.1Unknown
SarcolipinAA19646520.7Intracellular transport
Myeloid cell nuclear differentiation antigenN2937620.7Transcription regulation
PDGFA associated protein 1†AA49030020.6Cell cycle
Guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 3AA49025620.3Unknown
Chitinase 3-like 1 (cartilage glycoprotein-39)AA43411520.2Metabolism
Chromosome 14 open reading frame 2T9062120.1Unknown
Ataxin 2 related proteinAA02996319.9Unknown
Zinc finger protein 258AA28067719.9Development
DnaJ (Hsp40) homolog, subfamily B, member 1AA48175819.8Protein folding
Vesicle docking protein p115AA50434219.5Vesicle docking during exocytosis
Secretory carrier membrane protein 2R3280219.4Protein transport
Cas-Br-M (murine) ecotropic retroviral transforming sequenceN9423419.4Cell growth
Chromosome X open reading frame 12AA45527218.8Unknown
Decay accelerating factor for complement (CD55, Cromer blood group system)R0956118.6Complement pathway
CTF8, chromosome transmission fidelity factor 8 homologue (S cerevisiae)N5773118.5Unknown
Villin 2 (ezrin)AA41144018.5Cell structure
Ankyrin repeat domain 1 (cardiac muscle)AA48807218.5Defence response
Cytoskeleton associated protein 1AA50455418.5Cell structure