Differential gene expression between subconfluent cultured and native RPE cells sorted by SAM (FDR 1.4%). Genes are sorted by biological function
| Gene name | GenBank Acc No | Score (d) | Fold change* | Biological function |
|---|---|---|---|---|
| *Subconfluent/native RPE; †NA, undetectable in native RPE. | ||||
| 41 Genes overexpressed by subconfluent RPE | ||||
| Collagen, type XVI, α1 | R54778 | 6.2086958 | NA† | Cell adhesion |
| Integrin, α2 (CD49B, α2 subunit of VLA-2 receptor | AA463610 | 5.9930352 | NA | Cell adhesion |
| Thrombospondin 2 | H38240 | 5.5952514 | NA | Cell adhesion |
| Insulin-like growth factor binding protein 3 | AA598601 | 6.4324886 | NA | Cell cycle |
| Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | AA487700 | 5.9964532 | NA | Cell cycle |
| v-yes-1 Yamaguchi sarcoma viral related oncogene homologue | R83836 | 9.0139898 | NA | Cell cycle |
| Gap junction protein, β2, 26 kDa (connexin 26) | AA490688 | 5.8023088 | NA | Cell-cell signaling |
| Actin, β | R44290 | 9.7128396 | NA | Cytoskeleton |
| Caldesmon 1 | AA076063 | 7.83121 | 1.4 | Cytoskeleton; Muscle contraction |
| Reproduction 8 | AA465570 | 6.971362 | NA | Fertilisation |
| Tumour necrosis factor receptor superfamily, member 25 | W76376 | 6.1518795 | NA | Immune response, apoptosis |
| Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | AA488497 | 7.1312589 | NA | Immune response; development |
| Glutamate receptor, ionotropic, N-methyl d-aspartate 2A | H08933 | 5.6530117 | NA | Ion transport |
| Fucosyltransferase 4 (α(1,3) fucosyltransferase, myeloid specific) | R28447 | 5.7747679 | NA | Metabolism, carbohydrate |
| Microsomal glutathione S-transferase 1 | AA495936 | 6.6792779 | NA | Oxidative stress response |
| HECT type E3 ubiquitin ligase | R87212 | 7.9988818 | NA | Protein degradation |
| CAZ associated structural protein | R52873 | 5.6053736 | NA | Protein degradation |
| 26 serine protease | H04028 | 7.4968725 | NA | Protein degradation; protease |
| Elastase 3B, pancreatic | W40123 | 6.9857814 | NA | Protein degradation; protease |
| Aspartylglucosaminidase | R42153 | 8.4918723 | NA | Protein modification |
| SEC13-like 1 (S cerevisiae) | AA496784 | 10.424023 | NA | Protein transport |
| Adaptor related protein complex 3, β2 subunit | H11692 | 5.6233762 | NA | Protein transport |
| Peroxisome biogenesis factor 1 | AA427472 | 16.184002 | 2.4 | Proton transport |
| Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) | AA425853 | 7.7310373 | NA | RNA processing |
| Tyrosine kinase 2 | AA482128 | 7.5206556 | NA | Signal transduction |
| Inositol 1,4,5-triphosphate receptor, type 2 | AA479093 | 7.3995941 | NA | Signal transduction |
| Protein phosphatase 1, catalytic subunit, αisoform | AA443982 | 6.5780078 | NA | Signal transduction |
| Zinc finger protein 161 | AA232647 | 9.8923477 | 1.6 | Transcription regulation; defense response |
| Topoisomerase (DNA) II β170 kDa | AA504348 | 39.16232 | 16.9 | Transcription regulation; DNA topology |
| Synaptoporin | H98620 | 10.04159 | NA | Transport |
| Guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 3 | AA490256 | 5.6303528 | 1.5 | Transport |
| ATP binding cassette, subfamily B (MDR/TAP), member 10 | R83875 | 5.5977134 | NA | Transport |
| Human neuropeptide Y receptor Y1 (NPYY1) mRNA, exon 2-3 and complete cds. | R19478 | 13.345719 | NA | Unknown |
| Syndecan 2 (heparan sulfate proteoglycan 1, cell surface associated, fibroglycan) | H64346 | 9.7652404 | NA | Unknown |
| Integral membrane protein 2C | AA034213 | 7.76812 | NA | Unknown |
| Cisplatin resistance associated | W77812 | 7.6011771 | NA | Unknown |
| IMAGE:363103 | AA019511 | 7.0814745 | NA | Unknown |
| IMAGE:327676 | W23757 | 6.326244 | NA | Unknown |
| IMAGE:28309 | R40460 | 6.3181421 | 1.5 | Unknown |
| IMAGE:197888 | R96220 | 6.1341687 | NA | Unknown |
| S-phase 2 protein | T69532 | 5.8673496 | NA | Unknown |
| 5 Genes Underexpressed by Subconfluent RPE | ||||
| ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 | AA427472 | −6.104330 | −3.6 | Protein degradation; Acidification of organelles |
| Phosphofructokinase, platelet | R38433 | −6.797924 | −2.4 | Metabolism, glycolysis |
| HIV-1 rev binding protein 2 | W52273 | −7.691879 | −12.2 | Unknown |
| CDNA FLJ42496 fis, clone BRACE2035003 | AA410207 | −7.320713 | NA | Unknown |
| Solute carrier family 43, member 3 | N76193 | −6.725273 | −2.2 | Unknown |