No retinopathy | | No detectable retinal signs | | None |
Mild retinopathy (retinal arteriolar signs only) (figs 1, 2) | | One or more of the following arteriolar signs: • Generalised arteriolar narrowing • Focal arteriolar narrowing • Arteriovenous nicking • Arteriolar wall opacity (silver wiring) | | Modest* association with risk of clinical stroke, subclinical stroke, coronary heart disease, and mortality. |
Moderate retinopathy (fig 3) | | One or more of the following retinal signs: • Haemorrhage (blot, dot, or flame shaped) • Microaneurysm • Cottonwool spot • Hard exudates | | Strong† association with risk of clinical stroke, subclinical stroke, cognitive decline, and cardiovascular mortality |
Malignant retinopathy (fig 5) | | Moderate retinopathy plus optic disc swelling‡ | | Strong association with mortality |