Table 2

 Plasma levels of angiopoietin-1 (Ang-1) angiopoietin-2 (Ang-2), the soluble angiopoietin receptor Tie-2 (Tie-2), vascular endothelial growth factor (VEGF), its soluble receptor Flt-1, and von Willebrand factor (vWf) in patients with different manifestations of sickle eye disease

NR*NPR†PSR‡p Value
The PSR group comprised 22 with HbSC and two with Hb SS (11 men, mean age 35 (SD 11)), NPR comprised nine with HbSC disease and seven with HbSS (seven men aged 34 (10) years), while the NR group was five with HbSC and 11 with Hb SS (eight men, aged 32 (10) years). There were more patients with HbSC in the PSR group (p = 0.008) but the differences in sex and age were not significant (p = 0.936, p = 0.585 respectively).
NR, no retinopathy; NPR, non-proliferative retinopathy; PSR, proliferative retinopathy. *No retinopathy bilaterally; †no retinopathy unilaterally or NPR unilaterally or NPR bilaterally; ‡unilateral or bilateral PSR. Values are median (IQR) except for age, which is expressed as mean (SD). All p values by Mann-Whitney U test except for age which is by the Student’s unpaired t test.
Raw data
Ang-1 (ng/ml)2.2 (0.6–10.4)3.1 (1.2–13.8)2.0 (1.0–11.3)0.682
Ang-2 (ng/ml)6.0 (4.1–9.3)3.8 (2.0–10.0)4.7 (2.1–7.4)0.395
Tie-2 (ng/ml6.3 (5.0–36.0)9.0 (6.1–31.5)7.4 (5.8–22.0)0.714
VEGF (pg/ml)108 (61–728)116 (72–2650)137 (104–378)0.748
sFlt-1(ng/ml)35.0 (3–421)16.5 (0.3–500)18.8 (6.1–278)0.941
vWf (IU/dl)133 (108–164)147 (113–166)143 (122–161)0.690
Ratios
Ang-2/VEGF43.3 (15.5–60.5)20.5 (2.2–41.5)18.2 (11.3–59.1)0.290
Ang-2/Ang-12.4 (0.8–4.3)1.1 (0.6–2.3)1.6 (0.7–3.1)0.260
Ang-1/VEGF14.9 (3.8–27.1)13.6 (4.1–29.3)17.2 (4.8–40.6)0.856
(Ang-2/Ang-1)×100 /VEGF2.8 (0.2–5.7)0.8 (0.02–3.5)1.1 (0.15–4.4)0.013