Table 3

 Correlations among plasma angiogenic growth factors, their receptors, and von Willebrand factor in 23 AA subjects and 56 SCD patients

vWfVEGFsFlt-1Ang-1Ang-2Tie-2
Data presented as Spearman correlation coefficient (r) followed by p values. *p Values <0.05.
Ang-1: angiopoietin-1, Ang-2: angiopoietin-2, Tie-2: the angiopoietin receptor Tie-2, VEGF, vascular endothelial growth factor, sFlt-1, the VEGF receptor Flt-1; vWf, von Willebrand factor.
23 AA subjects
VEGF−0.026, 0.908
sFlt-10.099, 0.6240.627, 0.001*
Ang-10.269, 0.2150.505, 0.014*0.483, 0.020*
Ang-20.209, 0.3380.369, 0.0830.244, 0.2630.245, 0.260
Tie-2−0.074, 0.7390.546, 0.007*0.526, 0.010*0.501, 0.015*
56 SCD patients
VEGF0.120, 0.380
sFlt-10.114, 0.4010.882, <0.001*
Ang-10.279, 0.037*0.677, <0.001*0.610, <0.001*
Ang-20.165, 0.2250.645, <0.001*0.699, <0.001*0.591, <0.001*
Tie-20.317, 0.0170.743, <0.001*0.766, <0.001*0.743, <0.001*0.516, <0.001*