Table 4

 Correlations among angiogenic growth factors

vWfVEGFsFlt-1Ang-1Ang-2Tie-2
Data presented as Spearman correlation coefficient (r) followed by p values. *p Values<0.05.
Ang-1: angiopoietin-1, Ang-2: angiopoietin-2, Tie-2: the angiopoietin receptor Tie-2, VEGF: vascular endothelial growth factor, sFlt-1: the VEGF receptor Flt-1 and vWf: von Willebrand factor.
16 SCD patients with no retinopathy
VEGF−0.331, 0.210
sFlt-1−0.015, 0.9560.743, 0.001*
Ang-1−0.044, 0.8720.689, 0.003*0.492, 0.053
Ang-20.156, 0.5650.745, 0.001*0.881, <0.001*0.615, 0.011*
Tie-20.156, 0.5640.459, 0.0740.742, 0.001*0.656, 0.006*0.712, 0.002*
16 SCD patients with non-proliferative retinopathy
VEGF0.094, 0.730
sFlt-10.076, 0.7790.881, <0.001*
Ang-10.320, 0.2280.756, <0.001*0.773, <0.001*
Ang-20.037, 0.8910.869, <0.001*0.761, <0.001*0.681, 0.004*
Tie-20.413, 0.1120.701, 0.003*0.688, 0.003*0.822, <0.001*0.475, 0.063
24 SCD patients with proliferative retinopathy
VEGF0.290, 0.169
sFlt-10.215, 0.3130.935, <0.001*
Ang-10.477, 0.018*0.611, 0.002*0.470, 0.020*
Ang-20.247, 0.2450.549, 0.005*0.514, 0.010*0.589, 0.002*
Tie-20.295, 0.1620.871, 0.000*0.831, <0.001*0.642, 0.001*0.477, 0.019*