Table 5

 The effect of laser treatment (PRP) on plasma levels of angiopoietin-1 (Ang-1) angiopoietin-2 (Ang-2), the soluble angiopoietin receptor Tie-2, VEGF, sFlt-1 and vWf in eight patients with sickle haemoglobin C disease with “leaky PSR”

HbSC patients with “leaky PSR”p Value
Baseline (pre-laser)6 months post-laser
Values are median (IQR) except for age, which is expressed as mean (SD).
All p values by Wilcoxon’s paired test.
Raw data
Ang-1 (ng/ml)1.2 (0.6–9.5)0.5 (0.5–1.5)0.106
Ang-2 (ng/ml)3.6 (1.5–7.2)1.1 (1.1–2.0)0.022
Tie-2 (ng/ml6.0 (5.5–7.8)10.0 (7.6–10.6)0.022
VEGF (pg/ml)120 (72–138)115 (50–155)0.834
sFlt-1(ng/ml)15 (5–138)0.1 (0.01–3.6)0.402
vWf (IU/dl)133 (113–152)144 (138–148)0.673
Ratios
Ang-2/VEGF16.1 (12.2–101.1)20.0 (9.3–23.5)0.076
Ang-2/Ang-13.1 (1.0–4.3)2.3 (0.77–2.7)0.035
Ang-1/VEGF16 (4.8–28.2)10 (8.8–13.2)0.151
(Ang-2/Ang-1×100)/VEGF2.6 (0.5–8.0)1.7 (0.6–4.6)0.554