Table 2

 Measurement of visual acuity (ETDRS lines) (median (SD)) and gain in visual acuity (Snellen lines) after intravitreal injection of 4 mg, 8 mg, or 25 mg triamcinolone acetonide

TimeNoVisual acuityLogMAR unitsp ValueGain in visual acuity (Snellen lines)
The dosage was measured before filtration of the triamcinolone acetonide crystals. Peak time was defined as the time, at which visual acuity started to decline again. p Value, difference to the baseline value in each study group; NS, statistically not significant.
2 mg study group
Pre-injection80.18 (0.16)0.91 (0.39)
1 week60.19 (0.17)0.89 (0.44)0.92 (NS)0.50 (2.37)
1 month70.23 (0.21)0.83 (0.49)0.22 (NS)0.64 (2.93)
3 months80.22 (0.21)0.80 (0.39)0.20 (NS)0.39 (2.26)
6 months60.21 (0.22)0.86 (0.44)0.58 (NS)0.42 (2.06)
9 months30.23 (0.23)0.77 (0.40)0.20 (NS)0.83 (0.76)
Max during follow up80.23 (0.19)0.80 (0.39)0.09 (NS)1.13 (2.42)
At end of follow up80.19 (0.16)0.85 (0.38)0.57 (NS)0.63 (2.00)
Maximal gain80.05 (0.07)−0.10 (0.10)1.13 (2.42)
Duration of effect (months)80.92 (1.25)
Gain ⩾2 Snellen lines3/8 (38%)
5 mg study group
Pre injection100.18 (0.23)1.00 (0.53)
1 week40.08 (0.04)1.14 (0.26)0.48 (NS)−0.50 (5.68)
1 month80.24 (0.25)0.79 (0.43)0.21 (NS)0.88 (1.36)
3 months80.13 (0.09)0.99 (0.37)0.34 (NS)1.13 (1.81)
6 months60.30 (0.28)0.72 (0.46)0.15 (NS)1.33 (2.25)
9 months40.11 (0.10)1.11 (0.40)0.12 (NS)2.50 (2.08)
Max during follow up100.23 (0.23)0.82 (0.41)0.0121.90 (1.73)
At end of follow up100.21 (0.23)0.86 (0.42)0.076 (NS)1.20 (1.99)
Maximal gain100.05 (0.05)−0.18 (0.23)2.09 (1.76)
Duration of effect (months)102.30 (2.63)
Gain ⩾2 lines5/10 (50%)
13 mg study group
Pre injection90.15 (0.13)1.11 (0.61)
1 week60.23 (0.13)0.71 (0.30)0.0144.80 (4.49)
1 month80.22 (0.16)0.79 (0.39)0.0113.50 (4.14)
3 months90.26 (0.18)0.71 (0.39)0.0193.63 (4.75)
6 months80.26 (0.12)0.65 (0.27)0.0303.63 (4.44)
9 onths20.25 (0.21)0.70 (0.43)0.0374.50 (4.95)
Max during follow up90.30 (0.18)0.66 (0.40)0.0024.11 (4.37)
At end of follow up90.24 (0.13)0.71 (0.36)0.0233.56 (4.75)
Maximal gain90.15 (0.10)−0.46 (0.53)4.11 (4.37)
Duration of effect 9 (months)4.33 (3.91)
Gain ⩾2 lines7/9 (78%)