Clinical details of patients and their treatment
| Case No, age, sex | Diagnosis | Relevant history before treatment | Follow up (weeks) | Previous treatment | Maximum/current doseof sirolimus | Side effects of sirolimus therapy | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| CMO, cystoid macular oedema; CYC, cyclosporin; TAC, tacrolimus; INF, infliximab; AZA, azathioprine; Metho, methotrexate; IV MP, intravenous methylprednisolone; MMF, myclophenolate mofetil; OARx, off all treatment. | ||||||||||
| 1, 31, M | Anterior and intermediate uveitis | Episodes of CMO treated with orbital floor steroids. History of steroid induced raised intraocular pressure | 52 | TAC, depomedrone, orbital floor injections | 8 mg/4 mg | Acne, abdominal pain, deranged liver function tests | ||||
| 2, 37, M | Panuveitis | 52 | CYC, MMF, TAC | 10 mg/5 mg | Recurrent chest infections | |||||
| 3, 39, F | Panuveitis (unilateral) | Right eye vision reduced as a result of macular scarring secondary to chronic CMO. Repeated episodes of painful uveitis | 52 | CYC, MMF, TAC, IV MP | 8 mg/2 mg | Erythema nodosum | ||||
| 4, 30, M | Sarcoidosis, posterior uveitis | Repeated episodes of vitreous haemorrhage secondary to neovascularisation. Episodes of CMO treated with oral corticosteroids | 40 | TAC, MMF | 4 mg/OARx | Nausea | ||||
| 5, 46, F | Intermediate and posterior uveitis | Right eye vision reduced as a result of macular scarring secondary to chronic CMO. Episodes of CMO in left good eye treated with increased doses of oral corticosteroids. At commencement of trial persisting mild CMO in left eye | 60 | MMF, TAC, INF | 10 mg/0 mg (treatment withdrawn) | Breast oedema and scleroderma-like changes in the feet | ||||
| 6, 44, M | Behçet’s syndrome, posterior uveitis and vasculitis | 60 | CYC, AZA, TAC | 5 mg/OARx | Myagia in legs/painful feet in dorsal region | |||||
| 7, 45, M | Behçet’s syndrome. Posterior uveitis and vasculitis | Left optic atrophy secondary to optic nerve ischaemia. Right eye vision reduced because of old maculopathy. Marked systemic symptoms of Behçet’s syndrome | 52 | CYC, TAC | 8 mg/6 mg | Seborrhoeic dermatitis | ||||
| 8, 30, F | Behçet’s syndrome, posterior uveitis and vasculitis | Right eye vision lost because of retinal arterial occlusion | 26 | CYC, Metho, AZA, TAC, INF, IV MP | 12 mg/4 mg | Eczematous rash and severe headaches | ||||