Oral cardiovascular drug treatment in all patients whether hypertensive or not, with diagnoses of glaucoma and in controls (all treatments given before glaucoma diagnoses)
| Hypertension treatment | ||||||
|---|---|---|---|---|---|---|
| 1–1095 days before | 1–90 days before | |||||
| Yes | No | Odds ratio (95% CI) | Yes | No | Odds ratio (95% CI) | |
| *Aggregate value summing numbers for diuretic users and non-users. Probability values compared with non-use. | ||||||
| β Adrenergic blocking agents | ||||||
| Minus diuretic | 2037 | 2171 | 0.97 | 1357 | 1704 | 0.77* |
| Plus diuretic | 1515 | 1488 | (0.92 to 1.02) | 536 | 680 | (0.73 to 0.83) |
| p = 0.2 | p<0.0001 | |||||
| ACE inhibitors | ||||||
| Minus diuretic | 805 | 604 | 1.30 | 910 | 659 | 1.34* |
| Plus diuretic | 1454 | 1182 | (1.21 to 1.38) | 850 | 683 | (1.24 to 1.44) |
| p<0.0001 | p<0.0001 | |||||
| Calcium channel blockade | ||||||
| Minus diuretic | 1475 | 1331 | 1.18 | 1477 | 1331 | 1.16* |
| Plus diuretic | 1840 | 1549 | (1.12 to 1.25) | 926 | 801 | (1.09 to 1.24) |
| p<0.0001 | p<0.0001 | |||||
| All diuretic users | ||||||
| Use | 6695 | 6170 | 1.13 | 4570 | 4303 | 1.08 |
| Non-use | 20 385 | 20 910 | (1.08 to 1.18) | 22 510 | 22 777 | (1.03 to 1.14) |
| p<0.0001 | p<0.002 | |||||