Table 3

Oral prescriptions for β blocking agents, ACE inhibitors, and calcium channel antagonists in patients with and without later glaucoma

	Treatment period before glaucoma diagnosis
	1–1095 days							1–90 days
	Yes		No		Odds ratio*		95% CI	Yes		No		Odds ratio*		95% CI
*Odds ratios calculated as use against non-use.
(A) In patients with diagnoses of hypertension and/or recorded raised blood pressure
No diuretics
β blockade	908		858		1.06		0.96 to 1.17	713		785		0.90		0.82 to 1.00
							p = 0.2							p = 0.6
ACE inhibitors	600		458		1.32		1.17 to 1.49	706		496		1.44		1.28 to 1.61
							p<0.0001							p<0.0001
Calcium channel	765		620		1.24		1.11 to 1.38	858		672		1.29		1.16 to 1.42
antagonists							p<0.0001							p<0.0001
With diuretics
β blockade	1018		947		1.08		0.99 to 1.18	326		422		0.77		0.67 to 0.89
							p = 0.1							p<0.0005
ACE inhibition	1031		738		1.41		1.28 to 1.56	558		390		1.44		1.26 to 1.64
							p<0.0001							p<0.0001
Calcium channel	1170		910		1.30		1.19 to 1.42	562		437		1.29		1.14 to 1.47
antagonists							p<0.0001							p<0.0001
(B) In patients without diagnoses of hypertension or recorded raised blood pressure
No diuretics
β blockade	836	970		0.86		0.78 to 0.94		472	698		0.67		0.60 to 0.75
						p = 0.0015							p<0.0001
ACE inhibitors	160	114		1.41		1.11 to 1.79		166	129		1.29		1.02 to 1.62
						p = 0.006							p = 0.4
Calcium channel	532	526		1.01		0.90 to 1.14		468	461		1.02		0.89 to 1.16
antagonists						p = 0.9							p = 0.8
With diuretics
β blockade	377	396		0.95		0.83 to 1.10		168	199		0.84		0.69 to 1.04
						p = 0.5							p = 0.1
ACE inhibitors	303	314		0.97		0.82 to 1.13		206	214		0.96		0.79 to 1.17
						p = 0.7							p = 0.7
Calcium channel	512	430		1.19		1.05 to 1.36		279	257		1.09		0.92 to 1.29
antagonists						p = 0.008							p = 0.4