Summary of DNA microarray-based detection of the βigh3 gene in this study
| Type | Mutation | DNA microarray result | Sensitivity (%)* | Specificity (%)† | Positive predictive value (%)‡ | |
|---|---|---|---|---|---|---|
| Positive | Negative | |||||
| ACD, Avellino corneal dystrophy; GCD, granular corneal dystrophy; LCD I, lattice corneal dystrophy type I; RBCD, Reis–Bucklers corneal dystrophy. | ||||||
| *Sensitivity is defined as the number of true positives divided by the sum of true positives and false negatives. | ||||||
| †Specificity is defined as the number of true negatives divided by the sum of true negatives and false positives. | ||||||
| ‡Positive predictive value is defined as the number of true positives divided by the sum of true positives and false positives. | ||||||
| Normal | 27 | 0 | 100 | 100 | 100 | |
| Non-normal | 0 | 71 | ||||
| ACD | ||||||
| Heterozygotic | CGC/CAC | 57 | 0 | 100 | 100 | 100 |
| Non-heterozygotic | 0 | 41 | ||||
| Homozygotic | CAC | 10 | 0 | 100 | 100 | 100 |
| Non-homozygotic | 0 | 88 | ||||
| LCD I | ||||||
| Heterozygotic | CGC/TGC | 1 | 0 | 100 | 100 | 100 |
| Non-heterozygotic | 0 | 97 | ||||
| RBCD | ||||||
| Heterozygotic | CGC/CTC | 1 | 0 | 100 | 100 | 100 |
| Non-heterozygotic | 0 | 97 | ||||
| GCD | ||||||
| Heterozygotic | CGG/TGG | 2 | 0 | 100 | 100 | 100 |
| Non-heterozygotic | 0 | 96 | ||||