| Subject no. | Turnover rate (%/min) | ||
| F-HA | Hyaluronic acid | Saline | |
| 1 | 7.6 | 19.4 | 28.1 |
| 2 | 12.2 | 22.6 | 31.0 |
| 3 | 2.9 | 22.6 | 31.8 |
| 4 | 9.5 | 20.4 | 33.2 |
| 5 | 4.6 | 21.4 | 33.4 |
| 6 | 8.6 | 22.2 | 37.1 |
| 7 | 15.2 | 24.2 | 29.6 |
| 8 | 8.4 | 20.4 | 24.1 |
| 9 | 5.3 | 17.1 | 27.8 |
| 10 | 7.1 | 21.3 | 33.9 |
| Mean (SD) | 8.1 (3.6) | 21.7 (2.8) | 31.0 (3.7) |
The turnover rate of F-HA was significantly lower than those of hyarulonic acid and saline (p = 0.00012 and p = 0.00000022, respectively; Mann–Whitney test).