Table 1 Distribution of uveal melanoma initiation sites in various hemispheres and concentric zones, according to binary variables of patient and tumour characteristics

Binary variables	n	Hemispheres						Concentric zones relative to the equator
		T	N	p	U	L	p	Central	Peripheral		p
		T	N	p	U	L	p	Central	Eq–Os	Os–Li	p
Female	59	42	17	0.16	23	36	0.008	39	13	7	0.54
Male	51	29	22	0.16	33	18	0.008	37	10	4	0.54
⩽60 years of age	45	26	19	0.23	23	22	1.00	30	9	6	0.68
>60 years of age	65	45	20	0.23	33	32	1.00	46	14	5	0.68
Right eye	50	34	16	0.55	24	26	0.70	35	9	6	1.00
Left eye	60	37	23	0.55	32	28	0.70	41	14	5	1.00
No metastases	83	52	31	0.50	44	39	0.51	64	14	5	0.003*
Metastases	27	19	8	0.50	12	15	0.51	12	9	6	0.003*
TNM classification
T1-2	35	23	12	1.00	15	20	0.31	31	4	0	0.004*
T3-4	75	48	27	1.00	41	34	0.31	45	19	11	0.004*
COMS criteria
Small/medium	67	42	25	0.69	32	35	0.44	55	9	3	0.0003*
Large	43	29	14	0.69	24	19	0.44	21	14	8	0.0003*
Basal diameter/height ⩾2	54	38	16	0.24	28	26	0.85	45	7	2	0.002*
Basal diameter/height <2	56	33	23	0.24	28	28	0.85	31	16	9	0.002*
Intact Bruch membrane	83	54	29	1.00	41	42	0.66	62	13	8	0.03
Ruptured Bruch membrane	27	17	10	1.00	15	12	0.66	14	10	3	0.03
No retinal detachment	49	31	18	0.84	25	24	1.00	36	7	6	0.41
Retinal detachment	61	40	21	0.84	31	30	1.00	40	16	5	0.41
Spindle cell type	34	21	13	1.00	20	14	1.00	24	7	3	0.02
Mixed/epithelioid cell type	20	13	7	1.00	12	8	1.00	7	6	7	0.02
No scleral invasion	31	19	12	1.00	21	10	0.17	15	9	7	0.17
Scleral invasion	23	15	8	1.00	11	12	0.17	16	4	3	0.17

*These values remained statistically significant at the 0.05 level after multiplicity correction on the basis of 11 different analyses, using the Bonferroni approach for multiple comparisons.
Eq, equator; L, lower; Li, limbus; N, nasal; Os, ora serrata; T, temporal; U, upper.