| Clinical parameters | US4 and US7 genotype combinations* | |||||||||
| 4A7A | 4B7B | 4C7C | 4A7B | 4A7C | 4B7A | 4B7C | 4C7A | 4C7B | p† | |
| Affected eye | ||||||||||
| Right (n = 94) | 10 (11) | 30 (32) | 16 (17) | 10 (10) | 1 (1) | 13 (14) | 11 (12) | 1 (1) | 2 (2) | 0.038 |
| Left (n = 84) | 20 (24) | 39 (46) | 8 (10) | 4 (5) | 1 (1) | 8 (10) | 3 (4) | 0 | 1 (1) | |
| Gender | ||||||||||
| Male (n = 108) | 15 (14) | 42 (38) | 18 (17) | 7 (7) | 2 (2) | 12 (11) | 11 (10) | 0 | 1 (1) | 0.271 |
| Female (n = 70) | 15 (21) | 27 (39) | 6 (9) | 7 (10) | 0 | 9 (13) | 3 (4) | 1 (1) | 2 (3) | |
| HSV-1 blepharitis | ||||||||||
| Yes (n = 24) | 5 (21) | 9 (38) | 0 | 3 (13) | 2 (8) | 2 (8) | 3 (13) | 0 | 0 | 0.013 |
| No (n = 154) | 25 (16) | 60 (39) | 24 (16) | 11 (7) | 0 | 19 (12) | 11 (7) | 1 (1) | 3 (2) | |
| Corneal insensibility | ||||||||||
| Yes (n = 21) | 1 (5) | 13 (62) | 1 (5) | 3 (14) | 0 | 2 (10) | 1 (5) | 0 | 0 | 0.330 |
| No (n = 157) | 29 (18) | 56 (36) | 23 (15) | 11 (7) | 2 (1) | 19 (12) | 13 (8) | 1 (1) | 3 (2) | |
| AC sensitisation | ||||||||||
| Yes (n = 32) | 4 (13) | 15 (47) | 1 (3) | 4 (13) | 0 | 6 (19) | 2 (6) | 0 | 0 | 0.403 |
| No (n = 146) | 26 (18) | 54 (37) | 23 (16) | 10 (7) | 2 (1) | 15 (10) | 12 (8) | 1 (1) | 3 (2) | |
| Glaucoma | ||||||||||
| Yes (n = 39) | 6 (15) | 14 (36) | 5 (13) | 4 (10) | 0 | 5 (13) | 4 (10) | 0 | 1 (3) | 0.980 |
| No (n = 139) | 24 (17) | 55 (40) | 19 (14) | 10 (7) | 2 (1) | 16 (12) | 10 (7) | 1 (1) | 2 (1) | |
| HK entity: history | ||||||||||
| IEK (n = 63) | 9 (14) | 25 (40) | 9 (14) | 6 (10) | 1 (2) | 6 (10) | 5 (8) | 1 (2) | 1 (2) | 0.980 |
| HSK (n = 85) | 16 (19) | 32 (38) | 13 (15) | 4 (5) | 1 (1) | 11 (13) | 6 (7) | 0 | 2 (2) | |
| Conjunctivitis (n = 17) | 2 (12) | 8 (47) | 1 (6) | 2 (12) | 0 | 1 (6) | 3 (18) | 0 | 0 | |
| Other (n = 13) | 3 (23) | 4 (31) | 1 (8) | 2 (15) | 0 | 3 (23) | 0 | 0 | 0 | |
| HK entity: end follow-up | ||||||||||
| IEK (n = 50) | 8 (16) | 19 (38) | 7 (14) | 6 (12) | 1 (2) | 5 (10) | 3 (6) | 1 (2) | 0 | 0.991 |
| HSK (n = 93) | 16 (17) | 34 (37) | 15 (16) | 5 (5) | 1 (1) | 12 (13) | 7 (8) | 0 | 3 (3) | |
| Conjunctivitis (n = 16) | 3 (19) | 7 (44) | 1 (6) | 1 (6) | 0 | 1 (6) | 3 (19) | 0 | 0 | |
| Other (n = 19) | 3 (16) | 9 (47) | 1 (5) | 2 (11) | 0 | 3 (16) | 1 (5) | 0 | 0 | |
| Corneal transplantation | ||||||||||
| Yes (n = 49) | 9 (18) | 22 (45) | 4 (8) | 3 (6) | 0 | 8 (16) | 3 (6) | 0 | 0 | 0.631 |
| No (n = 129) | 21 (16) | 47 (36) | 20 (16) | 11 (9) | 2 (2) | 13 (10) | 11 (9) | 1 (1) | 3 (2) | |
| Outcome therapy | ||||||||||
| Improvement (n = 147) | 26 (18) | 54 (37) | 21 (14) | 11 (7) | 2 (1) | 17 (12) | 13 (9) | 1 (1) | 2 (1) | 0.922 |
| Stable (n = 5) | 0 | 4 (80) | 0 | 0 | 0 | 1 (20) | 0 | 0 | 0 | |
| Worse (n = 6) | 2 (33) | 1 (17) | 0 | 2 (33) | 0 | 1 (17) | 0 | 0 | 0 | |
*Data are the number (%) of corneal HSV-1 isolates assigned to the indicated US4 and US7 genotype combinations indicated.
†Results of a two-sided chi-square test. Statistical significant genotype associations are shown in bold.
AC sensitisation, inflammatory cells present in the aqueous chamber; HK, herpetic keratitis; HSK, herpetic keratitis; IEK, infectious epithelial keratitis.