| Week 12 (author, year) | Fixed | Non-fixed combination |
| Travoprost/Timolol (Hughes, 2005) | −8.0 | −8.8 |
| Latanoprost/Timolol (Diestelhorst, 2006) | −8.7 | −9.0 |
| Brimonide tartrate/Timolol (Goni, 2005) | −5.1 | −5.1 |
| Brimonidine tartrate/Timolol (Konstas, 2007) | −5.3 | −5.4 |
| Travoprost/Timolol (Schuman, 2005) | −7.6 | −7.8 |
| Dorzolamide/Timolol (Hutzelmann, 1998) | −4.8 | −4.8 |
| Dorzolamide/Timolol (Strohmaier, 1998) | −4.1 | −4.4 |