Ref no | Author | Publication year | Exam/op year | Follow-up year | Region | Index population (lens changes on clinical exam) | Comparison population (no lens changes on clinical exam) | Primary result |
1 | Podgor et al | 1985 | 1973–5 | 1979–82 | USA | n = 710 | n = 1235 | DRR = 1.39 |
2 | Klein et al | 1989 | 1980–2 | 1986–8 | USA | Patients with diabetes n = 182 | Patients with diabetes n = 1172 | Cataract subjects had lower survival adjusted for age and sex |
3 | Cohen et al | 1990 | 1982 | 1988 | UK | Patients with diabetes n = 108 | Patients with diabetes n = 184 | OR = 2.4 |
4 | Thompson et al | 1993 | 1982–4 | 1990 | UK | n = 394 | n = 79 | RR = 1.52 |
5 | Klein et al | 1995 | 1988–90 | 3 November 1993 | USA | n = 1573 | n = 3244 | HR = 1.28 |
6 | Klein et al | 1999 | 1980–2 | 8–16-year follow-up | USA | Diabetics n = 1441 | Diabetics n = 925 | HR = 0.83 type 1 DM |
HR = 1.22 type 2 DM | ||||||||
7 | West et al | 2000 | 2-year follow-up | USA | Total = 2520 n = ? | Total = 520 n = ? | OR = 2.23 | |
8 | Christen et al | 2000 | 1982 | Dec 1995 | USA | Male physicians with self-reported cataract n = 581 | Male physicians without self-reported cataract n = 18 088 | RR = 1.03 (multivariate adjusted) |
9 | Hennis et al | 2001 | 1988–92 | 4-year follow-up | Barbados | Black subjects n = 1863 | Black subjects n = 2432 | RR = 1.6 mixed opacities |
RR = 1.5 nuclear (multivariate adjusted) | ||||||||
10 | Wang et al | 2001 | 1992–4 | 1997–9 | Australia | Nuclear n = 309 | n = ? | RR = 1.5 (1.1 to 1.9) nuclear |
PSC n = 425 | RR = 1.5 (1.1 to 2.0) PSC | |||||||
Cortical n = 423 | RR = 1.3 (1.1 to 1.6) cortical (multivariate adjusted) | |||||||
11 | Reidy et al | 2002 | 1995–9 | 3.45-year follow-up (average) | UK | >65-year-olds n = 570 | 65-year-olds n = 748 | HR = 1.7 (1.1 to 2.7) Female |
HR = 0.9 (0.6 to 15) Male | ||||||||
12 | Borger et al | 2003 | 1990 | 2000 | The Netherlands | n = 298 | n = 5090 | HR = 0.94 (0.74 to 1.21) |
13 | McGwin et al | 2003 | 1994–6 | 31 December 2000 | USA | n = 86 | Subjects from ophthalmology clinics n = 98 | MRR = 3.2 (1.2 to 9.0) (multivariate adjusted) |
14 | Nucci et al | 2004 | 1987 | 1994 | Italy | Cortical n = 63 | n = 719 | HR 4.32 (1.13 to 16.4) nuclear opacity |
Nuclear n = 19 | HR = 18.3 (3.21 to 104.0) aphakia (multivariate adjusted) | |||||||
Mixed n = 44 | ||||||||
Aphakia n = 6 | ||||||||
15 | Knudtson et al | 2006 | 1987–8 | 2002 | USA | Total = 4926 n = ? | Total = 4926 n = ? | HR = 1.16 (1.03 to 1.32) p = 0.02 (multivariate adjusted) |
All analyses are age- and gender-adjusted. 95% CIs are given in parentheses where available.
DRR, death rate ratio; HR, hazard ratio; MRR, mortality rate ratio; OR, odds ratio; RR, relative risk.