Study | No of patients | Mitomycin C dose and drop regime | Control/recurrence rates | Follow-up period (months) |
Frucht-Perry et al9 | 3 | 0.02% four times daily for 10–22 days | 0% recurrence | 4–12 |
Wilson et al13 | 7 | 0.04% four times daily for 7 days in alternate weeks | ∼86% resolution 14% partial regression | 2–16 |
Frucht-Perry et al8 | 17 | 0.02–0.04% four times daily for 7–28 days | 35% recurrence | NA |
Daniell et al11 | 20 | 0.02–0.04% four times daily for 1–5 weeks in alternate weeks | 20% recurrence | 3–26 |
Shields et al10 | 10 | 0.04% four times daily for 1–4 weeks in alternate weeks | 0% recurrence | 6–50 |
Hirst et al15 | 26 | 0.04% four times daily for 3 weeks | 0.8% recurrence | 6–12 |
Current study | 91 | 0.04% four times daily for 2–3 weeks in alternate weeks | 0% recurrence in localised, 12.5% in recurrent group; 30% recurrence/persistence in diffuse group | 5.8–119.8 |