Table 4

Effect of therapy on outcome variables

Response variableModerateSevere
Control (n=25)AMT (n=25)p ValueControl (n=25)AMT (n=25)p Value
Primary outcome variable
 Epithelial healing rate0.8 (0.43 to 5.1)2.45 (0.48 to 5.8)0.00042.4 (0.27 to 4.8)2.8 (1 to 4.8)0.275
Secondary outcome variables
 Visual acuity
 LogMAR0.3 (0 to 2)0.2 (0 to 1.8)0.5312 (0.2 to 4)1.8 (0 to 4)0.709
 Lid involvement*0 (0.00)0 (0.00)0 (0.00)1 (4.00)0.500
 Presence of symblepharon*3 (12.00)1 (4.00)0.60916 (64.00)17 (68.00)1.00
 Corneal haze (%)0 (0 to 100)10 (0 to 50)0.98375 (0 to 100)80 (50 to 100)0.272
 Duration taken for epithelial healing (days)21 (7 to 90)15 (7 to 70)0.43360 (14 to 90)30 (12 to 90)0.219
 Corneal haze0 (0 to 2)1 (0 to 3)0.9833 (0 to 4)2 (0 to 4)0.272
 Grade of corneal haze*
  013 (52.00)12 (48.00)0.7062 (8.00)2 (8.00)0.538
  19 (36.00)10 (40.00)4 (16.00)4 (16.00)
  23 (12.00)2 (8.00)6 (24.00)8 (32.00)
  30 (0.00)1 (4.00)8 (32.00)9 (36.00)
  40 (0.00)0 (0.00)5 (20.00)2 (8.00)
 Corneal vascularisation*
  012 (48.00)13 (52.00)0.4320 (0)0 (0)0.804
  17 (28.00)8 (32.00)2 (8)3 (12)
  25 (20.00)4 (16.00)3 (12)5 (20)
  30 (0.00)0 (0.00)3 (12)3 (12)
  41 (4.00)0 (0.00)17 (68)14 (56)
  • * Data presented as number (%).

  • Data presented as median (range).

  • p<0.01, statistically significant.

  • AMT, amniotic membrane transplantation.