Correlation of corneal diameter, intraocular pressure and high-risk histopathology features with Reese–Ellsworth and International Classification for 67 eyes primarily enucleated for retinoblastoma
| Reese–Ellsworth Classification | International Classification | |||||
| Va | Vb | p Value | D | E | p Value | |
| Corneal diameter (mm) | ||||||
| No | 17/61 | 44/61 | 42/61 | 19/61 | ||
| Median (range) | 11.5 (10.5–13.0) | 12.0 (9.0–14.0) | 0.21 | 12.0 (9.0–13.0) | 12.0 (11.0–14.0) | 0.09 |
| Mean (SD) | 11.6 (0.7) | 11.8 (0.8) | 11.7 (0.7) | 12.0 (0.8) | ||
| Intraocular pressure (mm Hg) | ||||||
| No | 17/63 | 46/63 | 44/63 | 19/63 | ||
| Median (range) | 23.0 (9.0–49.0) | 22.0 (9.0–64.0) | 0.70 | 20.0 (9.0–52.0) | 35.0 (10.0–64.0) | 0.002 |
| Mean (SD) | 24.5 (11.1) | 26.3 (13.3) | 22.4 (10.5) | 33.7 (14.0) | ||
| Optic-nerve invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| None (%) | 0/19 (0) | 5/48 (10) | 4/47 (9) | 1/20 (5) | ||
| Prelaminar (%) | 13/19 (68) | 15/48 (31) | 0.21 | 22/47 (47) | 6/20 (30) | 0.026 |
| Laminar (%) | 4/19 (21) | 20/48 (42) | 18/47 (38) | 6/20 (30) | ||
| Postlaminar (%) | 2/19 (11) | 8/48 (17) | 3/47 (6) | 7/20 (35) | ||
| Choroid invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| None (%) | 3/19 (16) | 23/48 (48) | 23/47 (49) | 3/20 (15) | ||
| Focal (%) | 13/19 (68) | 11/48 (23) | 0.31* | 18/47 (38) | 6/20 (30) | <0.001* |
| Massive (%) | 3/19 (16) | 14/48 (29) | 0.025† | 6/47 (13) | 11/20 (55) | 0.013† |
| Ciliary-body invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| No (%) | 19/19 (100) | 41/48 (85) | 0.18 | 46/47 (98) | 14/20 (70) | 0.002 |
| Yes (%) | 0/19 (0) | 7/48 (15) | 1/47 (2) | 6/20 (30) | ||
| Iris invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| No (%) | 19/19 (100) | 43/48 (90) | 0.31 | 47/47 (100) | 15/20 (75) | 0.002 |
| Yes (%) | 0/19 (0) | 5/48 (10) | 0/47 (0) | 5/20 (25) | ||
| Anterior-chamber invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| No (%) | 19/19 (100) | 43/48 (90) | 0.31 | 46/47 (98) | 16/20 (80) | 0.025 |
| Yes (%) | 0/19 (0) | 5/48 (10) | 1/47 (2) | 4/20 (20) | ||
| Scleral invasion | ||||||
| No | 19/67 | 48/67 | 47/67 | 20/67 | ||
| No (%) | 19/19 (100) | 38/48 (79) | 0.052 | 46/47 (98) | 11/20 (55) | <0.001 |
| Yes (%) | 0/19 (0) | 10/48 (21) | 1/47 (2) | 9/20 (45) | ||