Table 2

Changes registered during the 2-year follow-up of functional and structural parameters in MS patients with MS attacks during the study and patients without attacks

No MS relapses (n=64)MS relapse (n=19)p
Functional parameters
 VA (LogMAR)−0.01−0.050.281
 Ishihara test−0.05−0.640.538
 Visual field, MD (dB)0.660.280.460
 Latency (ms)−0.231.620.529
 Amplitude (μV)0.22−1.980.008
OCT parameters
 Average RNFL Th (μm)−4.33−9.390.013
 Superior RNFL Th (μm)−3.50−7.060.373
 Nasal RNFL Th (μm)−2.13−10.590.015
 Inferior RNFL Th (μm)−6.29−7.550.769
 Temporal RNFL Th (μm)−5.38−8.050.490
 Macular volume (mm3)−0.07−2.290.007
 Macular thickness (μm)−16.78−8.180.078
GDx parameters
 TSNIT average (μm)0.959.830.205
 Superior average (μm)−0.013.560.217
 Inferior average (μm)0.38−1.010.660
 TSNIT SD (μm)−0.21−9.840.001
  • A value of p≤0.05 was considered to indicate statistical significance between the changes for both groups and these significant p values are marked with bold italic font in the table.

  • EDSS, Expanded Disability Status Scale; GDx, scanning laser ophthalmoscopy; MAR, minimum angle of resolution; MD, mean deviation; MS, multiple sclerosis; NFI, nerve fibre indicator; OCT, optical coherence tomography; RNFL, retinal nerve fibre layer; Th, thickness; TSNIT, temporal-superior-nasal-inferior-temporal; VA, visual acuity; VEP, visual evoked potentials.