Changes registered during the 2-year follow-up of functional and structural parameters in MS patients with MS attacks during the study and patients without attacks
| No MS relapses (n=64) | MS relapse (n=19) | p | |
| Functional parameters | |||
| VA (LogMAR) | −0.01 | −0.05 | 0.281 |
| Ishihara test | −0.05 | −0.64 | 0.538 |
| Visual field, MD (dB) | 0.66 | 0.28 | 0.460 |
| EDSS | −0.16 | −0.41 | 0.524 |
| Latency (ms) | −0.23 | 1.62 | 0.529 |
| Amplitude (μV) | 0.22 | −1.98 | 0.008 |
| OCT parameters | |||
| Average RNFL Th (μm) | −4.33 | −9.39 | 0.013 |
| Superior RNFL Th (μm) | −3.50 | −7.06 | 0.373 |
| Nasal RNFL Th (μm) | −2.13 | −10.59 | 0.015 |
| Inferior RNFL Th (μm) | −6.29 | −7.55 | 0.769 |
| Temporal RNFL Th (μm) | −5.38 | −8.05 | 0.490 |
| Macular volume (mm3) | −0.07 | −2.29 | 0.007 |
| Macular thickness (μm) | −16.78 | −8.18 | 0.078 |
| GDx parameters | |||
| NFI | 0.75 | 6.99 | 0.015 |
| TSNIT average (μm) | 0.95 | 9.83 | 0.205 |
| Superior average (μm) | −0.01 | 3.56 | 0.217 |
| Inferior average (μm) | 0.38 | −1.01 | 0.660 |
| TSNIT SD (μm) | −0.21 | −9.84 | 0.001 |
A value of p≤0.05 was considered to indicate statistical significance between the changes for both groups and these significant p values are marked with bold italic font in the table.
EDSS, Expanded Disability Status Scale; GDx, scanning laser ophthalmoscopy; MAR, minimum angle of resolution; MD, mean deviation; MS, multiple sclerosis; NFI, nerve fibre indicator; OCT, optical coherence tomography; RNFL, retinal nerve fibre layer; Th, thickness; TSNIT, temporal-superior-nasal-inferior-temporal; VA, visual acuity; VEP, visual evoked potentials.