CN context | Molecular events leading to CN | References |
Infectious keratitis | ||
Herpetic |
| 11 27–29 |
Fungal |
| 30 31 |
Bacterial | No data; potential VEGF implication | – |
Parasitic |
| 32 |
Hypoxia | ||
Contact lens wear |
| 18 19 33 34 |
Keratoplasty | ||
Post-keratoplasty |
| 35–39 |
LSCD and chemical burns | ||
Burns, injury |
| 3 22 |
LSCD | In rats with surgically induced LSCD, high levels of VEGF correlated with inflammation and CN | 40 |
Inflammatory disorders | ||
Ocular pemphigoid, atopic conjunctivitis, rosacea, graft rejection, Lyell's syndrome, Stevens–Johnson syndrome, GvHD | VEGF implication likely | 41 |
CN, corneal neovascularisation; GvHD, graft-versus-host disease; HIF, hypoxia-inducible factor; HSV, herpes simplex virus; IPAS, inhibitory PAS domain protein; LSCD, limbal stem cell deficiency; MMP, matrix metalloproteinase; MIP, macrophage inflammatory protein; SUR, sulphonyl urea receptor; sVR-1, soluble VEGF receptor 1; VEGF, vascular endothelial growth factor.