Table 3

Changes registered during the 2-year study of functional and structural parameters in MS patients with a previous episode of optic neuritis (ON-MS) or without (NON-MS)

	ON antecedent			Disease duration
	NON-MS	ON-MS	p	≤10 years	>10 years	p
Functional parameters
VA (LogMAR)	−0.02	−0.03	0.837	−0.03	−0.10	0.574
Ishihara test	−0.55	0.680	0.181	0.02	−0.82	0.384
Visual field, MD (dB)	0.70	0.23	0.326	0.72	0.24	0.290
EDSS	−0.29	0.02	0.396	−0.24	−0.16	0.819
Latency (ms)	2.00	−5.36	*0.006*	2.05	−1.13	*0.006*
Amplitude (μV)	−0.17	−0.38	0.787	−0.42	0.32	0.333
OCT parameters
Average RNFL Th (μm)	−5.28	−5.42	0.952	−6.56	−2.61	*0.025*
Superior RNFL Th (μm)	−4.17	−4.48	0.934	−5.27	−1.97	0.350
Nasal RNFL Th (μm)	−4.25	−3.00	0.704	−5.04	−1.41	0.242
Inferior RNFL Th (μm)	−5.75	−8.85	0.436	−7.07	−5.41	0.660
Temporal RNFL Th (μm)	−7.10	−2.63	0.212	−7.62	−2.16	0.108
Macular volume (mm³)	−6.80	−0.20	0.410	−7.36	−0.02	*0.035*
Macular average Th (μm)	−13.45	−9.98	0.345	−15.87	−8.76	0.123
GDx parameters
NFI	2.07	0.83	0.638	3.73	−4.25	<0.001
TSNIT average (μm)	2.67	1.59	0.732	2.00	4.04	0.483
Superior average (μm)	0.10	2.81	0.334	0.28	1.67	0.594
Inferior average (μm)	0.18	−0.02	0.948	−1.14	4.48	*0.045*
TSNIT SD (μm)	−2.14	−0.68	0.611	−2.54	0.42	0.262

Changes found during the study of functional and structural parameters in MS patients with disease duration less than and more than 10 years. A value of p≤0.05 was considered to indicate statistical significance between the changes for both groups and these significant p values are marked with bold italic form in the table.
EDSS, Expanded Disability Status Scale; GDx, scanning laser ophthalmoscopy; MAR, minimum angle of resolution; MD, mean deviation; MS, multiple sclerosis; NFI, nerve fibre indicator; OCT, optical coherence tomography; RNFL, retinal nerve fibre layer; Th, thickness; TSNIT, temporal-superior-nasal-inferior-temporal; VA, visual acuity; VEP, visual evoked potential.