Linear mixed effects regression measuring the effect of eyelid closure (ELC) on intraocular pressure (IOP) change*
| Coefficient (95% CI)† | p Value | |
| ELC versus control | ||
| Over all visits | 0.24 (−0.5 to 0.9) | 0.50 |
| At 1 h visit | 0.18 (−1 to 1.3) | 0.76 |
| At 1 day visit | 0.22 (−0.9 to 1.4) | 0.71 |
| At final visit‡ | 0.33 (−0.8 to 1.5) | 0.57 |
↵* Random intercepts were fitted at the patient and eye level.
↵† Coefficient represents difference in IOP change from baseline (mm Hg) in intervention versus control eyes. Positive values (as observed) for all the coefficients indicate that control did better than intervention eyes, although this was not statistically significant.
↵‡ IOP measured at a median of 12.9 h after eye drop instillation (IQR 12.1–13.6 h).