Table 1

Utility by BCVA in treated eye

Health state defined by BCVA category (letters; treated eye)	RESTORE^*	Lloyd et al12 ^†	Brown et al13 ^§
	Mean utility (SE)
1: 86–100	0.860 (0.034)^‡	0.830	0.839
2: 76–85	0.860 (0.014)	0.750	0.839
3: 66–75	0.813 (0.012)	0.750	0.783
4: 56–65	0.802 (0.014)	0.715	0.783
5: 46–55	0.770 (0.018)	0.680	0.732
6: 36–45	0.760 (0.027)	0.680	0.681
7: 26–35	0.681 (0.053)	0.530	0.630
8: 0–25	0.547 (0.083)	0.340	0.579

↵* Utility scores were calculated based on EQ-5D scores in RESTORE; EQ-5D scores were converted to utilities using social tariffs measured in a UK population.14 Mean utility for each BCVA state was calculated using a regression technique for repeated measurements at baseline, month 3, month 6 and month 12. Data from several measurement points were pooled to cover all possible health state transitions with a sufficient sample size. A possible trend effect in the pooled data was rejected (p<0.05).
↵† Patients underwent a Snellen visual acuity (VA) assessment and were categorised based on the better-seeing eye. Some adjustments were made to published values in order to convert VA ranges in Lloyd et al (obtained in a population of patients with diabetic retinopathy) to health states as defined in the current model.
↵§ Utilities were elicited from patients with diabetic retinopathy. Patients underwent a Snellen VA assessment and were categorised based on the better-seeing eye. Some adjustments were made to published values in order to convert VA ranges to health states as defined in the current model.
↵‡ Restricted to being greater than or equal to the utility in health state 2.
BCVA, best corrected visual acuity.