Table 1

Summary of the study patient disposition

Patient enrolmentReason for discontinuationSham TTTTTT
Enrolled5050
Randomised5050
Excluded from study
Erroneous diagnosis on review2
Discontinued treatment before first TTT42
Patient's decision11
Adverse event before first TTT*31
Received randomised treatment4448
Discontinued treatment before month 24411
Adverse event14
Patient's decision2
Unsatisfactory therapeutic effort34
Protocol deviation1
Remained on treatment at month 244038
  • * Sham transpupillary thermotherapy (TTT) (one massive submacular haemorrhage, one retinal pigment epithelium rip, one severe vision loss (>30 letters)), TTT (one severe vision loss (>30 letters)).

  • Sham TTT (one death), TTT (three deaths, one stroke).